Mechanisms Underlying Stress Fracture and the Influence of Sex and Race/Ethnicity

Abstract

This cross-sectional clinical study aims to examine potential mechanisms contributing to stress fracture risk. In Aim 1 we will perform advanced skeletal imaging along with gait-assessments in subjects with history of a single vs multiple vs no prior stress fractures. In Aim 2 we will perform advanced skeletal imaging to delineate variation in skeletal features according to sex and race/ethnic-origin that may contribute to or protect from stress fracture. To date, we have achieved the enrollment goal for Study 1 of 45 subjects, 42 of whom have completed all study visits. Data collection and cleaning are ongoing, and preliminary analysis has been performed for biomechanical and bone microarchitecture data. For Aim 2, 146 subjects (81% of targeted enrollment) have been enrolled and have completed testing. Data collection and cleaning are ongoing.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2019
Accession Number
AD1105505

Entities

People

  • Elizabeth Loranger
  • Kristin Popp
  • Mary L. Bouxsein
  • Sarah Gehman

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquisition
  • Biomechanics
  • Bone Fractures
  • Data Analysis
  • Electronic Mail
  • Finite Element Analysis
  • Health Services
  • High Resolution
  • Institutional Review Board
  • Lower Extremity
  • Mechanics
  • Medical Personnel
  • Microarchitecture
  • Spine
  • Statistical Analysis
  • X Rays
  • X-Ray Computed Tomography

Fields of Study

  • Medicine

Readers

  • Naval Personnel Management
  • Theoretical Analysis.
  • Trauma Surgery or Emergency Medicine.