Detection and Treatment of Advanced Prostate Cancer With Radiolabeled Transferrin Molecules
Abstract
We propose a new therapeutic paradigm for the treatment of castration resistant prostate cancer: targeting a shared pathobiological event upregulated by hyperactive MYC and mTOR with radiotherapy to ablate tumor cells. Because transferrin uptake into a cell is upregulated by hyperactive MYC or mTOR, we propose to synthesize a theranostic transferrin nanoparticle conjugate. A second objective is to show that we can image prostate cancer tumors with SPECT using the transferrin construct. The final objective is to show that the transferrin construct can ablate prostate cancer tumors with hyperactive MYC and/or mTOR.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2017
- Accession Number
- AD1106328
Entities
People
- Ning Zhao
Organizations
- University of California, San Francisco