A Pilot Trial of Remotely Supervised Transcranial Direct Current Stimulation (RS-tDCS) to Enhance Motor Learning in Progressive Multiple Sclerosis (MS)
Abstract
The purpose of this randomized, double-blind pilot clinical trial is to test the novel treatment approach of anodal transcranialdirect current stimulation (tDCS) to augment manual dexterity training targeted to rehabilitate fine motor functioning inindividuals living with progressive multiple sclerosis (MS). Treatment will be delivered to individuals at home using a state-ofthe-art remotely-supervised tele-medicine protocol, a major advantage for patients with respect to ease of access, feasibility,and minimal burden of in-clinic study visit participation. Specific Aim 1 is to determine the extent to which tDCS paired withmanual dexterity training improves fine motor execution on a grasp and lift task. We expect that the impairment in graspexecution will be significantly reduced with active tDCS versus sham tDCS from pre- to post-treatment. Specific Aim 2 is toassess the adaptation or learning of fingertip forces to object weight when tDCS is paired with manual dexterity training. Wepredict that active vs. sham tDCS paired with training will optimize the difference in the peak load force rates between the lightand heavy objects pre- to post-intervention. Training, material and database creation, and randomization/matching procedurescomplete. First participant enrolled and completed. Participant enrollment ongoing. Interim data analysis compiled forAmerican Academy of Neurology 2020 abstract.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1106336
Entities
People
- Leigh E Charvet
Organizations
- Grossman School of Medicine