Sensitization of Therapeutic-Resistant Pancreatic Cancer by Cancer Cell-Specific Drug Delivery

Abstract

In the first year of this three-year project, we have completed tasks following the timeline of our Statement of Work. We synthesize large amount of HMCD-SIM, enough for the entire project. We determined therapeutic efficacy of the HMCD SIM on pancreatic cancer cell lines; and confirmed the sensitization function of the HMCD-SIM. We have established two new pancreatic cancer cell lines, and tested assay conditions for measuring GASP-1 in clinical serum samples. For mechanistic investigation, we have identified IC50 of the HMCD-SIM in combination with GEM and CDDP in BXPC-3 and MiaPaCa-2 cells.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1106348

Entities

People

  • James S. Tomlinson

Organizations

  • University of California Regents

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Bladder Cancer
  • Cancer
  • Cell Line
  • Cell Membrane
  • Cells
  • Cellular Structures
  • Chemotherapeutic Agents
  • Culture Techniques
  • Department Of Defense
  • Intracellular Membranes
  • Medical Personnel
  • Membranes
  • Mitochondria
  • Neoplasms
  • Professional Development
  • Proteins

Fields of Study

  • Biology

Readers

  • Computational Modeling and Simulation
  • Oncology
  • Oncology (Cancer Research).