A Closed Loop Neural Prosthesis for Restoration of Function after Traumatic Brain Injury
Abstract
Significant progress has been made in developing activity-dependent stimulation (ADS) microdevices for use in both rodent and non-human primate (NHP) models of traumatic brain injury (TBI). Specifically, microdevices have been successfully assembled, benchtop tested for functionality, and deployed in a rodent model of TBI to determine the optimal time window for delivery of the therapy and time course of persistence of the ensuing therapeutic effects. Our results revealed that ADS treatment could be delayed up to 3 weeks after injury, while still improving the motor performance. Moreover, our results showed no drop in motor performance eight weeks after ADS treatment ended in rats that started to receive the therapy 1week after injury. Moreover, two generations of the NHP microdevice were developed, which were fully functional electrically at the bench top level, but have required additional work related to reliable, hermetic packaging/assembly approaches to ensure their long-term functionality during neurobiological experiments in vivo. Our work on this critical front is still ongoing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2019
- Accession Number
- AD1106951
Entities
People
- David J Guggenmos
- Pedram Mohseni
- Randolph J Nudo
Organizations
- Case Western Reserve University