Notch3 as a Tumor Suppressor in the Postpartum Mammary Gland

Abstract

The goal of this project is to determine the functions of Notch3 in the pathogenesis of postpartum breast cancer, with a focus on the regulation of brown adipose tissue repopulation in the postpartum mammary gland and its potential role in modulating tumor microenvironment, as well as the regulation of parity-induced mammary epithelial cells in the postpartum mammary gland. To our surprise, we found that the post-lactational involuting mammary microenvironment of Notch3 knockout mice suppressed tumor growth and metastasis. Moreover, the nonparous mammary microenvironment of Notch3 knockout mice showed a similar tumor-suppressive effect. We are currently determining whether Notch3 functions in the mammary epithelium or the stroma in this context. Our preliminary results suggest that Notch3 may regulate tumor-infiltrating lymphocytes.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1106981

Entities

People

  • Keli Xu

Organizations

  • University of Mississippi Medical Center

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Connective Tissue
  • Epithelial Cells
  • Fat Cells
  • Governments
  • Local Governments
  • Lymphocytes
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Patent Applications
  • Professional Development
  • Tissues

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics
  • Oncology (Cancer Research).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.