Modulating cancer genetics for immune regulation and breast cancer therapy
Abstract
In contrast to its important function in DNA repair, overexpression of human MSH2/6 mismatch recognition protein is driving the progression of basal like breast cancer and is associated with poor prognosis. This project will establish the molecular and biological function of MSH2/6. The first funding period has established several models to test this hypothesis. Our preliminary data suggest that this hypothesis is correct and will continue to study as the proposed aims delineate. We also found innovative connection between loss of MSH2 and the activation of Tregs, an immune suppressive T cell subtypes. During the next funding period we will complete the biological and immunological studies that test this hypothesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2020
- Accession Number
- AD1106986
Entities
People
- Weizhou Zhang
Organizations
- University of Florida