Genetic, Physiologic and Behavioral Predictors of Cardiorespiratory Fitness in Specialized Military Men
Abstract
Cardiorespiratory fitness (CRF) is a crucial performance requirement of specialized military occupations. Age and physical activity (PA) are established predictors of CRF, but it is not clear how these predictors combine with each other, and/or with genetic predisposition. The goal of this study was to derive inclusive explanatory models of CRF in U.S. Navy Explosive Ordnance Disposal (EOD) men, synthesizing conventional (e.g., age, body composition and physical activity) and novel influences (e.g., genetic variance). Forty male, active-duty EOD operators completed a graded exercise test (GXT) to assess maximal oxygen consumption (VO2max) and ventilatory threshold (VT) using the Bruce protocol. Aerobic performance was further quantified via time of test termination and time at which VT was achieved. Body composition was determined via dual x-ray absorptiometry, and physical activity was assessed by self-report. Genetic variants underlying human stress systems (5HTTLPR, BclI,2C/G, and COMT) were assayed. In univariate regression models, age, body composition, physical activity, and 5HTTLPR consistently predicted CRF and/or aerobic performance (R2 range = .07 to .55). Multivariate regression models routinely outperformed the univariate models, explaining 36-62 percent of variance. This study signifies a shift toward inclusive explanatory models of CRF and aerobic performance, accounting for combined roles of genetic, physiologic, and behavioral influences. The findings have implications for assessment, selection, and training of specialized military members; and may also impact mission success and survivability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 06, 2019
- Accession Number
- AD1107664
Entities
People
- Jeremiah Stump
- Lisa M. Hernández
- Marcus K. Taylor
- Matthew R. Schoenherr
Organizations
- Naval Health Research Center