Toward a Molecular Understanding of Noise-Induced Hearing Loss

Abstract

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have (a) Established the hair cell (HC) and supporting (SC) cell-specific translatomes of adult mouse inner ears and identified key regulators of OHC maturation and function; (b) Established the molecular changes induced by permanent and temporary threshold shift resulting noise exposure in HC, SC and whole inner ears, 6 and 24 hours after noise exposure; (c) We identified critical differences in the response of male and female mice to noise, and obtained approval to modify Specific Aim 3 to repeat the baseline as well as temporary and permanent threshold shift analysis using male and female mice separately.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2019
Accession Number
AD1107793

Entities

People

  • Ronna Hertzano

Organizations

  • University of Maryland School of Medicine

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Ear
  • Genetics
  • Health Services
  • Hearing Disorders
  • Medical Personnel

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Immunology and Pathology
  • Oncology and Biomarker-Based Cancer Detection.