PTSD Prevention Using Oral Hydrocortisone in the Immediate Aftermath of Trauma

Abstract

This project, PTSD Prevention Using Oral Hydrocortisone in the Immediate Aftermath of Trauma (PI: Rachel Yehuda), proposes to test a one-time prophylactic pharmacologic intervention administration of oral hydrocortisone (HCORT) for the prevention of post-traumatic stress disorder (PTSD) and related mental health disturbances. HCORT is a synthetic glucocorticoid similar to the body's own cortisol, and has numerous clinical uses as an anti-inflammatory agent. In response to acute stress, ample cortisol levels are critical to activating, and then containing, systems mobilized as part of the fight-or-flight response. There is evidence that people with lower cortisol levels at the time of trauma exposure are at elevated risk for PTSD.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1108303

Entities

People

  • Heather Bader
  • Migle Staniskyte
  • Rachel Yehuda

Organizations

  • Icahn School of Medicine at Mount Sinai

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Acquisition
  • Anxiety Disorders
  • Biomedical Research
  • Clinical Trials
  • Contracts
  • Covid-19
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  • Department Of Defense
  • Diseases And Disorders
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  • Governments
  • Health
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  • Intervention
  • Local Governments
  • Maryland
  • Medical Personnel
  • Mental Disorders
  • Mental Health
  • Monitoring
  • Patent Applications
  • Professional Development
  • Training
  • Traumatic Stress Disorder

Fields of Study

  • Medicine
  • Psychology

Readers

  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.
  • Toxicology/Environmental Toxicology