Targeted treatment of traumatic optic neuropathy inspired by neuroprotective adaptations of hibernation

Abstract

The primary objective of this research is to translate adaptive strategies used by hibernators to prevent vision loss associated with head injuries resulting in damage to the optic nerve. In Aim 1 (CY 19), we sought to optimize the selected drugs to maximize the viability of ganglion cells following mechanical compression of the optic nerve.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2020
Accession Number
AD1108348

Entities

People

  • Francisco Nadal Nicolas
  • Kiyoharu J. Miyagishima
  • Steven Stasheff
  • Wei Li

Organizations

  • National Institutes of Health

Tags

DTIC Thesaurus Topics

  • Alzheimer Disease
  • Blast Injuries
  • Carrier Proteins
  • Cell Physiological Processes
  • Confocal Microscopy
  • Diseases And Disorders
  • Enzyme Inhibitors
  • Eye Diseases
  • Head Injuries
  • Methylene Blue
  • Neuropathy
  • Optic Nerve
  • Redox Indicators
  • Reversible
  • Rodents
  • Torpor
  • Viability

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Image Processing and Computer Vision.
  • Mental Health of Military Veterans with Posttraumatic Stress Disorder (PTSD): Risk Factors, Prevalence, Symptoms, and Treatment.