Gulf War Illness as a Brain Autoimmune Disorder

Abstract

The primary goal of this study was to compare neuroimaging, immune-related genetics, and laboratory tests in veterans with GWI to those obtained from veterans with known autoimmune disorders, to determine the extent to which GWI reflects autoimmune abnormalities. Published findings from 193 completed acquisitions demonstrated the following: (1) brain function in GWI is indistinguishable from that of established autoimmune conditions, (2) specific human leukocyte antigen genes protect against brain structural alterations common in GWI; and (3) peripheral inflammatory markers are highly associated with GWI symptom domains involving the brain as well as with alterations in brain structure and axonal integrity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2020
Accession Number
AD1108364

Entities

People

  • Apostolos Georgopoulos

Organizations

  • University of Minnesota

Tags

Communities of Interest

  • Engineered Resilient Systems
  • Ground and Sea Platforms
  • Sensors

DTIC Thesaurus Topics

  • Autoimmune Diseases
  • Brain
  • Cells
  • Depression
  • Genetics
  • Health Services
  • Information Science
  • Medical Personnel
  • Persian Gulf Syndrome
  • Traumatic Stress Disorder

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and genetic basis of cancer.
  • Neuroscience

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech