A Novel Stress-Activated Inhibitor of Myelination
Abstract
In Multiple Sclerosis (MS) myelin and axons are damaged. At the beginning of the disease, the brain can repair itself by remyelination of damaged axons. With time, however, the repair ability of the brain deteriorates, and remyelination is no longer efficient or sometimes even possible. We discovered a novel inhibitor or remyelination that is present in MS plaques and we will test if it can be targeted to promote remyelination and protect axons. So far, we have discovered that this novel inhibitor delays the ability of oligodendrocyte progenitors (the precursors of the cells that will make myelin) to proliferate, migrate and differentiate. We are currently studying the molecular mechanisms by which the inhibitors exert these effects, because this may reveal novel ways to promote myelination. In addition, we have discovered that this inhibitor accelerate also remyelination after injury, using a toxin that deplete myelin-forming cells in an in-vivo model. These latest findings confirm that our novel inhibitors could be relevant to promote remyelination after a demyelination attack in Multiple Sclerosis patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1108433
Entities
People
- Leandro Marziali
- Maria L. Feltri
Organizations
- University at Buffalo