Mathematical Modeling of Hemodynamics in Trauma-Induced Shock and Closed-Loop Trauma Resuscitation
Abstract
Our long-term goal is to deliver automated closed-loop fluid and drug resuscitation systems for combat casualty and trauma care. We have prototyped and performed extensive animal studies of such systems for hemorrhagic shock and bum shock. However, animal studies alone may not be sufficient to demonstrate the safety of these systems. A key component to demonstrating the safety of these systems is to use mathematical models that describe the physiology of shock and its response to a full range of injuries and therapies. The focus of this grant is to establish such mathematical models. We performed 15 anesthetized swine studies of hemorrhagic shock and fluid therapy to achieve the data for modeling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 28, 2020
- Accession Number
- AD1108788
Entities
People
- George C. Kramer
Organizations
- University of Texas Medical Branch