Novel Anti Fibrotic Strategies In The Targeted Treatment And Prevention Of Post-Traumatic Ho And Enhancement Of Post-Traumatic Tissue Regeneration

Abstract

Neuromusculoskeletal injuries sustained in recent military conflicts have been notable for their number and complexity. Post-traumatic heterotopic ossification (HO) is the development of bone in the soft tissues and it is a significant sequela of these traumatic wounds occurring in approximately 60-70 of the war wounded. HO is the end product of a deranged fibroproliferative healing response and can render the extremity disfigured, painful and nonfunctional. Our group has studied this condition in combat related injuries at the cell and molecular level for the greater part of the last decade. In addition to identifying a progenitor cell population involved in this healing response, we have also identified TGF-b1 mediated tissue fibrosis to be one of the key initial steps in the pathogenesis of HO and that dysregulation of the SMAD3 intracellular signaling protein in conjunction with a fibrotic microenvironment to be a central feature of the bone forming process.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2020
Accession Number
AD1108818

Entities

People

  • Jaira Ferreira-de-vasconcellos
  • Leon Nesti

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemistry
  • Combat Injuries
  • Data Analysis
  • Fibrosis
  • Gene Expression
  • Growth Factors
  • Heterotopic Ossification
  • Military Medicine
  • Osteogenesis
  • Pcr Testing
  • Peptide Growth Factors
  • Residual Limbs
  • Stem Cells
  • Three Dimensional
  • Tissues
  • Wound Healing

Fields of Study

  • Medicine

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.