Targeting a Novel Androgen Receptor-Repressed Pathway in Prostate Cancer Therapy
Abstract
The central hypothesis of the proposal is that PKD plays a crucial role in limiting the effectiveness of ADT by increasing prostate cancer survival through upregulating AURKA expression. AURKA encodes the protein Aurora A kinase, which is a master cell cycle regulator that is often dysregulated in human cancers. Our data demonstrated an important role of PKD in regulating Aurora A stability, implying that PKDs role in cancer cell survival and proliferation may be mediated through Aurora A. The primary goal of this study is to investigate the potential roles of PKD in mediating therapeutic resistance to ADT and to investigate the impact of PKD SMI-based combination therapies to curtail ADT-induced therapy resistance. This study will fill an important knowledge gap in signaling mechanisms and therapeutic targeting of PKD in the context of ADT-induced therapy resistance in prostate cancer. If successful, it will provide the basis for translating PKD-targeted agents to the clinical settings.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2020
- Accession Number
- AD1110023
Entities
People
- Qiming J. Wang
Organizations
- University of Pittsburgh