Reengineering of Antibiotics Informed by Antimicrobial Resistance Mechanisms

Abstract

Report on progress of using cryo-electron microscopy as a tool to understand the key interactions that the oxazolidinone antibiotic family make with the bacterial ribosome as well as the means that the bacterial use to evolve resistance to this class of drugs.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1110031

Entities

People

  • Matthew Belousoff

Organizations

  • Monash University

Tags

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Bacteria
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Crystal Lattices
  • Crystal Structure
  • Crystals
  • Data Set
  • Electron Density
  • Electron Microscopes
  • Electron Microscopy
  • Electronic Mail
  • Electrons
  • Health Services
  • Hydrogen Bonds
  • Infection
  • Microbiology
  • Mitochondrial Proteins
  • Organic Chemistry
  • Pharmacology
  • Proteins
  • Staphylococcus Aureus
  • Therapy
  • X Rays

Fields of Study

  • Biology

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Molecular and Cellular Biochemistry
  • Organizational Process Management (OPM).

Technology Areas

  • Microelectronics