Epigenomic Landscape of Primary Prostate Cancer in African American Men

Abstract

We hypothesize that differences in the epigenomic landscape may interact with somatic genomic alterations and tumor microenvironment to drive racial disparities in prostate cancer outcomes and that epigenomic alterations may serve as prognostic molecular biomarkers in AA PCa. Here, we propose to conduct the largest study to comprehensively define the epigenomic landscape of PCa arising in AA men with long-term oncologic follow-up and/or tumor somatic sequencing and immune microenvironment characterization. This research will identify unique epigenomic drivers of aggressive biology and adverse PCa outcomes among AA patients, elucidating novel biological underpinnings of this critical health care disparity.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2020
Accession Number
AD1110034

Entities

People

  • Tamara L Lotan

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Acquisition
  • African Americans
  • Biological Markers
  • Biomedical Research
  • Cancer
  • Data Analysis
  • Department Of Defense
  • Disparities
  • Electronic Mail
  • Health
  • Health Care
  • Health Services
  • Internet
  • Maryland
  • Medical Personnel
  • Metastasis
  • Methylation
  • Neoplasms
  • Patent Applications
  • Procurement
  • Prostate
  • Prostate Cancer
  • Quality Control
  • Standards
  • Universities

Fields of Study

  • Biology

Readers

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  • Oncology
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