Development of Unique Serum Biomarkers with Mass Spectroscopy for Diagnosis of Veterans with Chronic Posttraumatic Headache versus Idiopathic Chronic Migraine
Abstract
Chronic Migraine (CM) is characterized by suffering greater than or equal 15 headaches/month with greater than or equal 8 of these being migraine. TBI during deployment (DTBI) occurred in 15-20 percent of Service Members (SM) deployed to OEF/OIF campaigns and the TBI has been followed by significant headache burden in the large majority subjects with persistence of the headache problem for up to 15 years. Our data found that CM was present in over 50 percent of the Veterans with DTBI (TBIS) recruited for this study as opposed to only 3 percent of controls (CS) consisting of deployed Veterans without a TBI. Clinically, it was noted that 60 percent of the TBIS with CM also had PTSD and Severe Depression (SDep). The pathophysiology of CM is unknown. This study was and exploratory study to search for biomolecules that relate to CM that would result from stress/defense mechanisms in the brain and then are shed into the serum. The study employed Electrospray Ionization MassSpectroscopy (ESI-MS)sera of TBIS compared to CS to search for unique biomolecules related to CM. These biomolecules could serve as biomarkers for CM and also provide clues to pathophysiology as well as possible therapeutic approaches for CM. For the study 92 TBIS and 70 CS were recruited. Subgroups were formed from these recruits based on presence or absence of DTBI, CM, PTSD and SDep and Infrequent Headache (IFH- less than or equal 9 headaches/month). ESI-MS was carried out in binary fashion comparing subgroups with different combinations of these variables. The Mass Spectroscopy profiles obtained demonstrated the unique profiles for DTBI with and without CM could be obtained. Likewise profiles of DTBI and CM with and without PTSD and SDep were obtained. The profiles suggested multiple biochemical mechanisms were involved. Much further work will be needed to clarify the results. The work does suggest there is a specific profile for CM with unique biomechanistic functions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2018
- Accession Number
- AD1110039
Entities
People
- J.R. Couch
- Jay S Hanas
Organizations
- University of Oklahoma