Quantitative Assessment of Post-Traumatic Osteoarthritis by Multi-Modal Optical Coherence Tomography
Abstract
Evidence from osteoarthritis (OA) studies suggests that there is a narrow time window in the early stages of the disease when cartilage can be functionally restored to reduce further degeneration. Small internal cartilage damages due to traumatic joint injuries are hard to detect with the traditional imaging technologies but pose a significant risk of inducing OA later. Our goal is to develop a non-destructive and label-free combination of optical coherence tomography (OCT) based methods for early detection of PTOA by assessment of mechanical strength, which is dependent upon both GAG and collagen, through our novel method for optical coherence elastography (OCE) based on fringe washout, and of collagen by itself through polarization-sensitive OCT. While our progress has been slowed by the current COVID-19 pandemic, we have demonstrated, for the first time to our knowledge, volumetric assessment of the mechanical properties of cartilage and bone. We anticipate successful completion of our aims as our campus re-opens for research activities. This work will provide the first optical method capable of complete non-destructive assessment of sub-surface cartilage degeneration for PTOA diagnosis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1110045
Entities
People
- B. H. Park
- Jin Nam
Organizations
- University of California, Riverside