Transplantation of Photoreceptors for Restoration of Sight

Abstract

We studied the survival and integration of the retina/RPE allografts transplanted from healthy rats into rats with retinal degeneration. Studies were performed using retina/RPE sheet explants (1mm in diameter) were harvested from wild type Long Evans and Sprague Dawley rats (P25-P70). Recipients were RCS (>P150) and S334ter-3 (>P60) rats after complete degeneration of photoreceptors. Optical coherence tomography (OCT) was used to monitor reattachment of the ret na and the implant survival over time. Integration of the transplant with the host inner retina was assessed after explanation, using histology and immunohistochemistry.

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Document Details

Document Type
Technical Report
Publication Date
Sep 25, 2020
Accession Number
AD1110538

Entities

People

  • Daniel Palanker

Organizations

  • Stanford University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Allografts
  • Biological Pigments
  • Boundaries
  • Central Nervous System
  • Electrophysiological Phenomena
  • Epithelium
  • Eye
  • Gene Therapy
  • Histology
  • Implantation
  • Liquid Crystal Displays
  • Nervous System
  • Ophthalmology
  • Retinal Diseases
  • Scientific Research
  • Tissues
  • Transplants

Readers

  • Medical Imaging.
  • Neuroscience
  • Vision Science/Vision Psychology/Cognitive Neuroscience.

Technology Areas

  • Biotechnology