Overcoming Immunological Barriers for Preclinical Studies of Cardiac Stem Cell
Abstract
Many veterans suffer from ischemic cardiomyopathy partly resulting from exposure to Agent Orange. Due to the limited supply of donor hearts and potential complications from chronic immunosuppressive therapy, investigators have turned to therapeutic approaches aimed at improving myocardial function, namely, cell transplantation. The purpose of this proposal is to generate non-immunogenic human embryonic stem cell-derived left ventricular cardiomyocytes as a potential off-the- shelf candidate for cardiac cell transplantation
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1110610
Entities
People
- Arash Pezhouman
Organizations
- University of California, Los Angeles