Molecular and Cellular Determinants of Malignant Transformation in Lung Squamous Cell Carcinoma
Abstract
During the second funding period we completed Major Tasks 1 and 2 and partially completed Major Task 3. The areas of interest were identified in 22 squamous cell lung cancer patients and isolated by LCM. Genomic DNA was isolated from these areas and whole exome sequencing was performed. The data has been analyzed for the progression-associated, premalignant- and malignant-specific mutations. The mutational data is being analyzed in the pathway context. Gene copy number alterations were identified by the analysis of the sequencing data. Multiplex immunofluorescence staining to determine the spectrum of infiltrating immune cells in tumor and premalignant microenvironment is ongoing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1110691
Entities
People
- Steven M. Dubinett
Organizations
- University of California, Los Angeles