Prostate Tissue Gene Expression Patterns Predict Prostate Tissue Inflammation, Aggressive Prostate Cancer, and a Poorer Prognosis Among Black and White Men

Abstract

Black men have a 63 percent higher prostate cancer (PC) risk than white men, and a more than 2-fold higher mortality. Our objective is to determine the connection between immune cell infiltration and gene expression of pro- and anti-inflammatory messengers in prostate tissue in black and white men with PC. We also will determine the link between differential gene expression on aggressive vs. non-aggressive PC and clinical progression following treatment in black and white men with PC. We hypothesize increased immune cell invasion believed to be pro-carcinogenic in the prostate will increase the expression of genes involved with immune system signaling and cell cycle regulation in the prostate, leading to an aggressive PC. This effect may be stronger in black men who in general have greater systemic inflammation.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2020
Accession Number
AD1110707

Entities

People

  • Jay Fowke

Organizations

  • University of Tennessee

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cell Physiological Processes
  • Covid-19
  • Data Analysis
  • Data Sets
  • Department Of Defense
  • Gene Expression
  • Immune System
  • Inflammation
  • Maryland
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Statistical Analysis
  • Tennessee
  • Tissues
  • Universities

Readers

  • Immunology and Pathology
  • Prostate Cancer Biology.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.