Preventing the Production of Autoreactive B Cells in Systemic Lupus Erythematosus
Abstract
The main goals of our research project have not changed and consist in studying the defective central B cell tolerance in MISTRG6 humanizedmice engrafted with hematopoietic stem cells (HSCs) isolated from the bone marrow of patients with systemic lupus erythematosus (SLE). Wealso proposed to test whether PTPN22 blockade may prevent the production of developing autoreactive B cells in humanized mice engrafted with HSCs from patients with SLE injected with LTV-1 PTPN22 inhibitor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2019
- Accession Number
- AD1110821
Entities
People
- Eric Meffre
Organizations
- Yale University