Injectable Mesh Nanoelectronics for Brain Mapping and Modulation
Abstract
We have developed and exploited a new paradigm for electrical mapping and modulation of brain activity which we call syringe-injectable mesh electronics. Mesh electronics features tissue-like mechanical properties and connectivity and can be injected into and integrated with brain tissue with minimal invasiveness, enabling the unique capability to record from and stimulate the same neurons and neural circuits over long periods of time. In the first year of this project we advanced injectable mesh nanoelectronics capabilities for in-vivo studies, creating new silicon nanowire field-effect transistor (NWFET)-based mesh electronics, developed a strategy to protect the electronics against degradation in physiological environments, and initiating in-vivo physiological recording with this new tool, demonstrating for the first time multiplexed single-unit neuronal spike detection with the SiNW FET mesh, and highlighting its unique ability to record neuronal activities at subcellular resolution. Also, as a first step toward enable in-vivo neuron subtype electrophysiology, we functionalized mesh electronics with peptides and antibodies capable of targeting different cell types and achieved cell type-specific electrophysiological recording, selectively targeting neurons versus glia. Finally, we made a conceptual breakthrough in the design of 'neuron-like electronics' (NeuE) that enables unprecedented integration within the brain at the subcellular level, yielding an endogenous distribution of all major cell types as well as stable multiplexed single-unit recording of individual cells. The structure of NeuE appears to facilitate migration of endogenous neural progenitor cells, possibly due to its biomimetic neurite-like topographical features. We explored ways to further minimize the damage from implantation, and its ensuing immune response, by testing and optimizing injection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 14, 2020
- Accession Number
- AD1110903
Entities
People
- Adam Cohen
Organizations
- Harvard College