Innovative Ultrasonic Methods for the Diagnosis and Monitoring of Pulmonary Fibrosis

Abstract

Idiopathic pulmonary fibrosis (IPF), affecting 200,000 patients in the U.S leads to changes in the micro-architecture of the parenchyma, such as thickening of the alveolar walls. This study investigates the use of ultrasound to detect these changes, by exploiting ultrasound multiple scattering by the air-filled alveoli. In a highly scattering media such as the parenchyma, ultrasound propagation follows a diffusion process which can be characterized using the Diffusion Constant. We hypothesized that in a fibrotic lung, the thickening of the alveolar wall reduces the amount of air, minimizing the scattering events and changing the scattering pattern.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1111583

Entities

People

  • M. Müller

Organizations

  • North Carolina State University

Tags

DTIC Thesaurus Topics

  • Diseases And Disorders
  • Frequency Shift
  • Health Services
  • Lung Diseases
  • Medical Personnel
  • Scattering
  • Tomography
  • Ultrasounds
  • Waves
  • X-Ray Computed Tomography

Readers

  • Acoustical Oceanography.
  • Immunology and Pathology
  • Medical Imaging.