Comprehensive Study of Acute Effects and Recovery After Concussion
Abstract
Utilizing a multi-dimensional research model, this study integrates biomechanical, clinical, neurobiological, and neuroradiological markers of mTBI, with the ultimate goal to more fully inform a neurobiopsychosocial model of mTBI risk, recovery and outcome. With the goal of baseline testing 900 athletes and enrolling 50 injured athletes and 50 contact and 50 non-contact controls over the course of 3 years, the project has surpassed all targets ahead of schedule and on budget. Over the life of the study, we enrolled 1174 at baseline and accrued 107 concussed athletes in the multidimensional post injury protocol, along with 137 non-injured control athletes. All groups completed follow up evaluations within 6 hours of injury, 48 hours after injury, and 8, 15, and 45 days after injury. These evaluations included advanced brain neuroimaging, blood biospecimen collection, and clinical testing measures assessing balance, neurocognition, symptoms, and psychological health, and data from the Head Impact Telemetry System (HITS). Several lines of preliminary analysis have been presented at national research meetings, submitted for publication, and published in peer-reviewed journals. Further data analyses are underway, with our investigative team developing advanced database platforms and analysis techniques. Ongoing collaboration with coinvestigators and our project partners has guided us to a successful execution of this comprehensive study, which will lead to advancing the science of mTBI and improving clinical care in military, sports, and civilian populations. This projects focus on high school and lower level collegiate athletes makes it fully distinct from the NCAA-DoD CARE Consortium. The combined findings from this study are predicted to have major translational impact on the science and clinical care for concussion in all populations, including the settings of military medicine and civilian trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2019
- Accession Number
- AD1111686
Entities
People
- Michael McCrea
Organizations
- Medical College of Wisconsin