Improving Ischemia Reperfusion Injury in Vascularized Composite Tissue Allotransplantation Via Histone Deacetylase Modulation

Abstract

This work proposes to investigate the impact of histone deacetylase (HDAC) drug inhibition or deletion on the tolerance of limb warm and cold ischemia reperfusion injury (IRI) in scenarios relevant to limb transplantation using mouse models for experimentation. Limitations in tolerated ischemia times limits the scope of donors that can be considered for any particular vascularized composite allotransplant (VCA) recipient. Mitigating IRI therapeutically would have significant impact on the applicability of VCA to military personnel suffering catastrophic limb or tissue loss.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2020
Accession Number
AD1111976

Entities

People

  • Matthew H. Levine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Government Procurement
  • Governments
  • Health Services
  • Inhibition
  • Ischemia
  • Law
  • Maryland
  • Medical Personnel
  • Military Personnel
  • Modulation
  • National Governments
  • Pennsylvania
  • Procurement
  • Technology Transfer
  • Universities
  • Vascular Diseases

Fields of Study

  • Biology

Readers

  • Neuroscience
  • Oncology (Cancer Research).
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology