The Role of Mesothelial Omentin in Ovarian Cancer Progression

Abstract

We hypothesize that omentin (ITLN1) suppresses ovarian cancer progression by sequestering lactotransferrin (LTF) from its receptor (LRP1) on the ovarian cancer cells and adipocytes, and that lactotransferrin promotes ovarian cancer cells motility and growth. The most significant finding in this research period are (1) exogenous omentin suppresses ovarian cancer cells motility and invasive potential, (2) matrix etalloproteinase-1 (MMP1) mediated the effects of omentin on suppressing ovarian cancer cells motility and invasive potential, (3) ITLN1 abrogates LTFs effects on ovarian cancer cells motility and invasive potential (4) omentin suppressed ovarian cancer growth by enhancing insulin-dependent glucose in adipocytes via facilitative glucose transporter (GLUT4/SLC2A4), and (5) exogenous omentin suppressed ovarian cancer progression in vivo.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1111981

Entities

People

  • Kay-Pong Yip

Organizations

  • University of South Florida

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Biomedical Research
  • Cell Line
  • Cell Movement
  • Cells
  • Connective Tissue
  • Culture Media
  • Department Of Defense
  • Gene Expression
  • Mass Spectrometers
  • Mass Spectrometry
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Proteins
  • Tissues
  • Universities

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).