Targeted Nanobubble Technology to Control Diabetic Macrophage Function

Abstract

Purpose and Scope. The use of micro- and nanobubble systems combined with ultrasound (US) for drug and gene delivery hasgained attention because the US can be used to trigger and enhance delivery via sonoporation. The objective of the proposedresearch is to develop a novel approach of miR-21 mimic cargo delivery using targeted gas nonobubbles. The delivery isanticipated to improve plasticity of injury-site macrophages in diabetic ulcers thus, facilitating resolution of inflammation andpromote wound healing. Results and Significance. I) Successfully formulated macrophage targeted cationic nanobubbles (mNB)which are sufficiently stable to allow for adequate therapy time. II) optimized the delivery of mNB in excisional wounds that wastrackable under US imaging using Vevo2100. In preliminary experiments, the delivery resulted in improved wound closure in adelayed wound healing mice model of miR-21lysM cre.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1112047

Entities

People

  • Sashwati Roy

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood
  • Buoyancy
  • Cells
  • Covid-19
  • Delivery Of Health Care
  • Department Of Defense
  • Gene Delivery
  • Governments
  • Health
  • Inflammation
  • Macrophages
  • Medical Personnel
  • Physical Properties
  • Plastic Properties
  • Professional Development
  • Research Facilities
  • Standards
  • Technology Transfer
  • Therapy
  • Ultrasounds
  • Universities
  • Wound Healing

Fields of Study

  • Medicine
  • Physics

Readers

  • Data Mining and Knowledge Discovery.
  • Medical Imaging.
  • Oncology (Cancer Research).