Targeting the Endotheliopathy of Trauma in Hemorrhagic Shock and Traumatic Brain Injury with Freeze-Dried Platelets
Abstract
The goal of this project is to test the therapeutic potential of freeze dried platelets-FDPlts (Thrombosomes)- in disease conditions characterized by 1) inflammation, 2) vascular instability and 3) coagulation disturbances, which are all components of the endotheliopathy of trauma (EOT) (refs). Aside from their hemostatic properties, this proposal aims to also determine the mechanisms of action of the freeze dried platelets (FDPlts (Thrombosomes)) on the EOT in traumatic brain injury (TBI) and shock induced acute lung injury (ALI); all conditions with few if any effective treatment options. We hypothesize that FDPlts (Thrombosomes) will have potent hemostatic properties comparable to fresh platelets and that they will attenuate and mitigate the endotheliopathy of trauma (EOT) in TBI and HS induced ALI. We hypothesize that FDPlts (Thrombosomes) can be used as a stand-alone early therapy to mitigate outcomes in trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2020
- Accession Number
- AD1112058
Entities
People
- Alpa Mahuvakar
- Shibani Pati
Organizations
- University of California, San Francisco