Invention of a Genetic Toolkit for Immunomodulatory Gut Bacteria to Expedite the Development of New Crohn's Disease Therapeutics
Abstract
The incidence and prevalence of Crohn's disease has increased steadily over the past several decades in the developed world with a major impact on quality of life. Unfortunately, current therapies are often unsuccessful in controlling inflammation and there is an urgent need to develop more effective therapeutic strategies. Our team is addressing this challenge by pursuing the following innovative outcomes: (i) Identifying novel natural NF-kB suppressive bioactives to support the development of a new therapeutics that mimic immunoregulation in the healthy gut (ii) Establishing a rational genetic approach to effectively bioprospect the gut microbiota, and; (iii) Providing new insights into the NF-kB suppressive activities of the gut microbiota and the structural diversity of the molecules that underpin it. The significance of this research is that it will catalyse the transition of gut microbiota research from an observational and associative paradigm to a translational one.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1113590
Entities
People
- Jakob Begun
Organizations
- University of Queensland