Humanized Mouse Model as a Platform for Continuous Propagation of P. vivax in a Laboratory Setting
Abstract
There is currently no available methodology for continued propagation of Plasmodium vivax parasite in the laboratory setting and this inherent difficulty of working with the parasite makes vaccine and drug development extremely challenging. Yet, P. vivax malaria has a tremendous negative worldwide impact on the human population and is an ever-present issue for the military personnel working in the endemic countries. The objective of this proposal is to develop methods based on a new liver-chimeric mouse model that would allow for continual cultivation of P. vivax entire life cycle.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2019
- Accession Number
- AD1113714
Entities
People
- Ashley Vaughan