Defining the Role for Descending Pain Modulation and Reward-Aversion Processes Towards the Development of Chronic Pain in Endometriosis
Abstract
Endometriosis, a condition in which uterine tissue grows outside the uterus, is a debilitating disease, affecting millions of women, is the leading cause of chronic pelvic pain (CPP), and is often unresponsive to existing treatments. Unfortunately, women's reproductive health has lacked investigation in biomedical research, which is warranted given that approximately 1 in 10 women worldwide have endometriosis. Further research on the biopsychosocial mechanisms contributing to endometriosis-associated pain is necessary to better inform treatment and prevention and is the goal of the current proposal. In respects to the COVID-19 pandemic, while recruitment and data collection have been stalled, the research team has used this time to publish several papers related to the project, including the publication of the projects first review paper, with another currently under review and three papers in preparation (two reviews; preliminary resting state data) along with attending various webinars and trainings related to the project. Currently due to COVID-19, research imaging has limits. During this time the research team has been discussing alternatives to counteract the setbacks that the project is currently facing. Recent discussion includes the following ideas: Reaching out to Harvard Medical School (HMS) affiliated hospitals to aid in recruitment, adopting another imaging modality (i.e., fNIRS) that does not have COVID-related restrictions, and exploring adding another research scanning site at one of the other HMS affiliated hospitals.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2020
- Accession Number
- AD1113718
Entities
People
- Christine B Sieberg
- David Borsook
Organizations
- University of Michigan