Development of Ultrasound-Guided Photoacoustic Imaging for Noninvasive Detection of Metastatic Lymph Nodes in Melanoma Patients

Abstract

In melanoma skin cancer patients, determination of whether a malignancy has spread is the single most important factor used to develop a therapeutic plan and to predict prognosis. In most cases cancer cells initially spread through regional lymph nodes. The presence of malignant cells in the first lymph node to which a tumor drains - known as the sentinel lymphnode (SLN) - is a harbinger of distant metastases and a low survival rate. Therefore, clinical evaluation for the presence of regional lymph node metastases is critical. We propose to develop an advanced, in-vivo, clinically translatable noninvasive imaging technology, i.e., integrated ultrasound (US) and photoacoustic (PA) imaging, capable of immediate and accurate assessment of SLN micro-metastases in real time. The central theme of this application is to design, build and test a prototype of the SLN ultrasound-guided photoacoustic (USPA) imaging tool.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2020
Accession Number
AD1114547

Entities

People

  • Stanislav Emelianov
  • Yiying Zhu

Organizations

  • Georgia Tech Research Corporation

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Absorption Spectra
  • Acquisition
  • Biomedical Research
  • Cancer
  • Cell Line
  • Data Acquisition
  • Detection
  • Imaging Techniques
  • Lymph Nodes
  • Medical Personnel
  • Melanoma
  • Models
  • Neoplasms
  • Photoacoustic Tomography
  • Professional Development
  • Skin Cancer
  • Ultrasounds

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Oncology (Cancer Research).
  • Oncology and Biomarker-Based Cancer Detection.