Functional and Molecular Mechanisms Underlying Detrusor-Sphincter Dyssynergia (DSD) in SCI
Abstract
In patients with spinal cord injury (SCI), neurogenic lower urinary tract dysfunction due to detrusor overactivity (DO) during urine storage and detrusor-sphincter dyssynergia (DSD) during voiding is a great risk factor of urological problems in people with spinal cord injury (SCI). The overall aim of this proposal is therefore to seek to identify the functional and molecular mechanisms of voiding dysfunction and DSD, as well as the involvement of neurotrophic factors such as brain-derived neurotrophic factor (BDNF), following SCI. In the third year of the project, the major achievements included; (1) time dependent progression of lower urinary tract dysfunction such as DSD in association with BDNF upregulation in the bladder in SCI mice, especially focusing on the mice up to 6 weeks after SCI and (3) effects of early-started BDNF inhibition on lower urinary tract dysfunction such as DO and DSD/inefficient voiding in the SCI model. These results indicated that SCI induces time dependent bladder and urethral sphincter dysfunctions similar to SCI humans, which are associated with the changes in molecular expressions in the bladder (e.g., BDNF) and bladder afferent pathways (e.g., ASIC channels).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2020
- Accession Number
- AD1115172
Entities
People
- Naoki Yoshimura
Organizations
- University of Pittsburgh