The MexTAg Collaborative Cross: Understanding Genetic Modifiers in Mesothelioma
Abstract
This is the second progress report for award CA170299. In the last 12 months we have overcome a major setback associated with breeding the last 20 CC-MexTAg groups and have successfully bred and asbestos exposed all 70 groups CC-MexTAg groups onto the asbestos exposure study. Moreover, we now have complete data from 55 of 70 groups and are able to perform interim analysis. The additional 15 CCMT groups remain on study and we expect to have complete data by May 2021.Interim analysis demonstrates significant variation in disease phenotype, with a 3-fold change in median survival and disease latency between groups. We have identified a variety of qualitative trait loci (QTL) for each of 5 traits (phenotypes) being assessed and are currently investigating genes and regulatory elements associated with each QTL. These data will be used to interrogate human mesothelioma datasets over the next 12 months. To date, we have completed or are about to complete Aims 1 and 2. Initiation of Aim 3 will occur in H2 2020, once US DoD human ethics approval has been received. We are on track to achieve all stated aims by the end of May 2021.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2020
- Accession Number
- AD1115918
Entities
People
- Richard Lake
- Scott Fisher
Organizations
- University of Western Australia