Implantable Nanochannel System for the Controlled Delivery of Osteogenic Growth Peptide
Abstract
We have fabricated implantable, medical grade polyether ether ketone (PEEK) devices housing two silicon nanofluidic membranes for the sustained and constant release of osteogenic growth peptide (OGP) and tested their tolerability and efficacy to stimulate local bone growth in New Zealand White Rabbits. The devices, which can be used to treat osteopenia, can be implanted without external fixation. Use of PEEK ensures some flexibility and radiolucency. In vitro release studies were performed with the microfabricated silicon nanochannel membranes to determine the optimal nanochannel size (3.5 nm) to achieve sustained, constant release. OGP release was relatively linear over the two-month period, and at day 60, cumulative release profiles targeted ~30 ug of peptide. Vehicle releasing (PBS:PBS), mixed (PBS:OGP), or treatment releasing (OGP:OGP) devices were implanted on both sides of the spine in rabbits (n=12) for two months to assess the promotion new bone formation in vivo. Signs of osteogenesis were evaluated via X-ray, cone beam CT, and histology. Overall, we demonstrate that our nanofluidic platform for constant OGP delivery can result in local ossification near the device delivery site.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2020
- Accession Number
- AD1115922
Entities
People
- Carly S Filgueira
Organizations
- Houston Methodist Research Institute