Glutamate Neuroexcitotoxicity in GWI

Abstract

The objective of the proposed research is to examine whether dietary exposure to food additives containing glutamate may be contributing to symptoms in Gulf War Illness (GWI). The rationale for proposed study comes from data in the fibromyalgia field which suggests that reducing the consumption of dietary glutamate can reduce over-excitation in the nervous system, leading to symptom improvement. Since there is almost complete symptom overlap between fibromyalgia and GWI, it is of utmost importance to test this diet as a low-cost treatment option in GWI patients. Herein, we report on our preliminary findings of this research which include highly significant and clinically meaningful improvements in overall symptom load, pain, fatigue, quality of life, cognitive function, and mood symptoms.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1116573

Entities

People

  • Kathleen F Holton

Organizations

  • American University

Tags

DTIC Thesaurus Topics

  • Business Administration
  • Clinical Trials
  • Data Analysis
  • Diseases And Disorders
  • Glutamates
  • Management Personnel
  • Medical Personnel
  • Nervous System
  • Neuropathy
  • Organizational Structure
  • Persian Gulf Syndrome
  • Personnel Management
  • Professional Development
  • Psychiatry
  • Quality Of Life
  • Societies
  • Students

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.