Functional genetics for predisposition to development of Type 2 Diabetes in obese individuals

Abstract

Obesity is a major risk factor for Type 2 Diabetes (T2D) yet the majority of obese subjects never develop T2D and their metabolic tissues never lose insulin sensitivity. This suggests the key role of genetic predisposition to T2D development in obesity. This proposal assesses for the first time whether single nucleotide variations (SNVs) within three genes, PIKFYVE, FIG4 and VAC14, encoding proteins that assemble in a single complex to regulate glucose homeostasis, are associated with T2D in obesity. We performed exome sequencing in abdominal fat derived from bariaric surgeries of 96 morbidly obese individuals with or without T2D (48 subjects/group).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1116905

Entities

People

  • Assia Shisheva

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Adipose Tissue
  • Connective Tissue
  • Data Science
  • Diabetes
  • Diabetes Mellitus
  • Diseases And Disorders
  • Genetics
  • Information Science
  • Insulin
  • Metabolic Diseases
  • Metabolism
  • Neuropathy
  • Nucleotides
  • Observation
  • Regression Analysis
  • Tissues
  • Type 2 Diabetes

Fields of Study

  • Biology
  • Medicine

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Technology Areas

  • Biotechnology