Mechanisms of Resistance to Androgen Deprivation Therapy in Advanced Castration Resistant Prostate Cancer (CRPC)

Abstract

The overall hypothesis is that expression of the dipeptidase DPP4 is downregulated in prostate cancer (PCa) as a mechanism of resistance to androgen deprivation therapy (ADT). My overall objective is to demonstrate that DPP4 downregulation is a mechanism of ADT-resistance and PCa progression and to identify the specific pro-survival growth factor/cytokine targeted by DPP4 for degradation and its associated signaling cascade. Aim 1 will assess the effect ofDPP4 downregulation and overexpression on the sensitivity of PCa xenografts to castration. Aim 2 will identify the pro-survival growth factor/cytokine targeted by DPP4 for degradation and the downstream signaling cascades effected. Aim 3 will extend the significance of DPP4downregulation into primary PCa and CRPC clinical specimens and assess the interaction ofDPP4 inhibition with ADT.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2020
Accession Number
AD1116935

Entities

People

  • Joshua W. Russo

Organizations

  • Beth Israel Deaconess Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Androgen Receptors
  • Androgens
  • Biomedical Research
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Cytokines
  • Governments
  • Growth Factors
  • Health Services
  • Hormones
  • Humanities
  • Inhibition
  • Inhibitors
  • Institutional Review Board
  • Local Governments
  • Lymphocytes
  • Medical Personnel
  • Neoplasms
  • Professional Development
  • Prostate Cancer
  • Proteins
  • State Governments
  • Therapy

Readers

  • Prostate Cancer Biology.