Early Precursor Escape and High-Grade Serous Carcinogenesis
Abstract
The subject of this grant is the origin of high-grade serous carcinoma, The purpose of this grant is to develop the hy0 that precursor cells with TP53 mutations escape from the fallopian tube into the peritoneal cavity, where they eventually undergo malignant transformation to form high-grade serous carcinomas. The research focuses on linking the precursor and malignant phases of serous carcinogenesis across space and time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2020
- Accession Number
- AD1116966
Entities
People
- Christopher P Crum
Organizations
- Brigham and Women's Hospital