Review of Open Access and DoD Biomarker-Related Databases for Exposure Assessment Research
Abstract
The 711th HPW requires the ability to rapidly respond to military exposure events with recommendations for measurable biomarkers of exposure and effect. Over the past 10 years, publications related to biomarkers of exposure have increased, which coincides with a paradigm shift to a more individualistic exposure assessment where biological burden and genetic factors contributing to susceptibility are included. This report is a review of a subset of open access databases and Department of Defense databases. In total, ten open access databases were evaluated and tested for utility using three military exposures of interest: copper, particulate matter, and organophosphates. The Comparative Toxicogenomics Database provided the most comprehensive and useful results by documenting biological specimens collected, concentrations of chemicals and markers in samples, and citations for corresponding literature. Six Department of Defense databases were selected for analysis in this report. Our analysis found that these databases provide information related to individual warfighter health and exposure but do not adequately identify measurable biomarkers and methods for detection that can be applied in exposure assessments. The move towards comprehensive individual exposure assessment requires synthesis of data from multiple databases to inform new and updated exposure assessment protocols for military relevant exposures.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2020
- Accession Number
- AD1117071
Entities
People
- Brett Edwards
- Christin Duran
- Jennifer S. Kerr
- Logan Hyder
Organizations
- Universal Energy Systems