A Systems Biology Approach to Radiation Biodosimetry and the Host-Environment Interaction: Applications to Mass Casualty Triage in the Polytrauma Patient

Abstract

We have successfully utilized rodent models of radiation and thermal injury to examine existing and novel biomarkers for radiation exposure alone, thermal injury alone, or their combination. We quantified markers at varying levels in skin, blood, and major organs. The emphasis was on pan-omic work, but we related findings to ongoing and previous histopathology and immunohistochemistry (IHC) to elucidate relationships between biomarker change and potential clinical impacts in samples collected. A focus was on identification of candidate markers that are obtained least invasively (i.e., blood or skin biopsy) and therefore can be applied readily to the field for rapid assessment of military and civilian populations that have had potential radiation exposure and/or thermal injury.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2020
Accession Number
AD1117183

Entities

People

  • Lauren Moffatt
  • Robert J Christy

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Biological Markers
  • Biomedical Research
  • Burns
  • Casualties
  • Civilian Population
  • Computational Biology
  • Data Analysis
  • Department Of Defense
  • Environment
  • Experimental Design
  • Health Services
  • Histology
  • Histopathology
  • Identification
  • Ionizing Radiation
  • Medical Personnel
  • Patent Applications
  • Professional Development
  • Radiation
  • Standards
  • Students
  • Systems Biology
  • Technology Transfer
  • X Rays

Readers

  • Molecular and genetic basis of cancer.
  • Nuclear and Radiation Engineering.
  • Trauma Surgery or Emergency Medicine.