Engineering Biomaterial-Based Therapies for Improved Lymphatic Function and the Resolution of Chronic Inflammation in Posttraumatic Osteoarthritis

Abstract

In year 2 of the project, we demonstrated that lymphatic function was reduced during mid and late- stages of osteoarthritis in the rat medial meniscus transection model. This reduction may be due to cytokines and inflammation found in osteoarthritis synovial fluid. In addition, we provided evidence that biomaterials (such as hyaluronan, liposomes and PEG microgels) can be intra-articularly injected into rat knees to increase retention of drugs within the joint for as long as 3 weeks. The application of these carriers in conjunction with therapeutics (such as resolvins, hyaluronan, exercise and mesenchymal stem cells) will be investigated in year 3 to treat osteoarthritis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2020
Accession Number
AD1117367

Entities

People

  • Brandon Dixon

Organizations

  • Georgia Tech Research Corporation

Tags

DTIC Thesaurus Topics

  • Arthritis
  • Biological Factors
  • Biomedical And Dental Materials
  • Blood
  • Cartilage
  • Cells
  • Chemistry
  • Joint Diseases
  • Joints (Anatomy)
  • Lymphocytes
  • Medical Personnel
  • Orthopedics
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells
  • Therapy

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech