A Microfluidic Method to Define the Role of Skin Microenvironment in Melanomagenesis
Abstract
Exposure to environmental UV radiation (UVR) is considered a major etiological factor for skin cancer including malignant melanoma, the deadliest form of skin cancer. Since the ambient UVR exposure is greatest during midday hours, tasks such as long periods of training exercises for soldiers or sailors can influence the daily UVR exposure. Deployment of military personnel over the past decade in countries with near maximum annual averages of solar radiation potentially increases their risk of melanoma. Mutations in genes (specifically NRAS and BRAF) that activate mitogen activated protein kinase signaling are the major drivers of cutaneous melanoma and found in >80 percent melanomas. Majority of nevi, which are collections of growth arrested melanocytes, also harbor mutations in BRAF, but do not necessarily act as precursors of melanoma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1117690
Entities
People
- Vijayasaradhi Setaluri
Organizations
- University of Wisconsin–Madison