Characterization and Therapeutic Targeting of a Novel Metastasis-Suppressive Pathway in Colon Cancer
Abstract
Cancer metastasis, the spread of cancer to other organs in the body, is the ultimate cause of death in most cancer patients. Cancer cells often hijack regulatory pathways in the cell to achieve dysregulated gene expression of the key components of these pathways. However, as most regulatory programs are yet to be annotated, the systematic discovery of such pathologic regulatory pathways remains elusive. Here, we report, for the first time, the development of a new computational framework, termed RPADA, that helps identify novel regulators that drive human cancers. We have applied PRADA to models of colon cancer metastasis to identify a previously unknown pathway, mediated by the protein RBMS1, as a suppressor of metastatic progression. This study introduces an entirely new approach for studying complex human diseases such as cancer and will benefit veterans, their beneficiaries, and the patient population in general.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2020
- Accession Number
- AD1117698
Entities
People
- Albertas Navickas
Organizations
- University of California