Targeting the Gut Microbiome to Treat Post-Traumatic Osteoarthritis
Abstract
While osteoarthritis (OA) is a debilitating condition with no disease modifying treatments, the gut microbiome may play a role in its development and progression. The establishment of a disease modifying treatment of OA has immense ramifications,including improved quality of life, lowered economic burden of treatment, and increased productivity of patients with OA. The purpose of this project is to study the pathogenic role of the microbiome in the development of OA as well as to develop microbiome-based treatments of the disease. Fecal microbiota transplants (FMTs) will be used to examine the causal relationship between microbiome dysbiosis that may develop in veterans diagnosed with post-traumatic osteoarthritis (PTOA)and belonging to the Military and Veteran Microbiome: Consortium for Research and Education (MVM-CoRE). Treatment ofPTOA with microbiome pre and probiotics has begun and we find the dietary supplement hydrolyzed hylaline cartilage (hHC)to have protective effects on cartilage degeneration in a mouse model of PTOA. Despite institutional shutdowns caused by theCOVID-19 pandemic, significant progress has been made on the first two objectives of this project, with progress expected to continue apace on all objectives.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2020
- Accession Number
- AD1118293
Entities
People
- Michael Zuscik
- Steven R Gill
Organizations
- University of Colorado Boulder