Median Lethal Dose (LD50) Associated with Intravenous Exposure to VX in Hairless Guinea Pigs

Abstract

Dermal interstitial fluid, the fluid found in the spaces between skin cells, is a potentially rich reservoir of information about the bodys response to nerve agent exposure. Hairless guinea pigs have been selected as the most appropriate animal model for an upcoming study comparing the biomarkers found in interstitial fluid with those in blood from o-ethyl-S-(2-diisopropylaminoethyl) methyl phosphonothiolate (VX)-exposed animals. However, the median lethal dose (LD50) associated with VX intravenous exposure is unknown in this animal model. Using an up-and-down procedure, the 24 h LD50 for VX intravenous exposure was determined to be 12.1 micro g/kg with a 95% confidence interval of 7.3 to 22.1 micro g/kg.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2020
Accession Number
AD1118387

Entities

People

  • Jeffry S. Forster
  • Julie A. Renner
  • Linnzi K. Wright
  • Ruth W. Moretz

Organizations

  • United States Army Soldier Systems Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Anatomy
  • Animals
  • Biological Markers
  • Body Weight
  • Cells
  • Department Of Defense
  • Environment
  • Environmental Protection
  • Epilepsy
  • Information Operations
  • Intervals
  • Jugular Vein
  • Laboratory Animals
  • Lethal Dosage
  • Lethality
  • Magnetic Resonance
  • Mass Spectrometry
  • Nerve Agents
  • Nuclear Magnetic Resonance
  • Rodents
  • Standards
  • Technical Information Centers
  • Toxicity
  • Veins

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Combustion and Flow Dynamics.
  • Neurotoxicology

Technology Areas

  • Space